George Hajishengallis, D.D.S., Ph.D. is the Thomas W. Evans Centennial Professor at the University of Pennsylvania, School of Dental Medicine. His field of interest lies at the host-microbe interface, where his work has illuminated novel mechanisms of microbial dysbiosis and inflammation, as well as inflammation resolution and tissue regeneration. He combines basic and translational research leading to innovative approaches to clinical problems, such as exemplified by periodontitis. Read more.


Li X, Wang H, Schmidt CQ, Ferreira VP, Yancopoulou D, Mastellos DC, Lambris JD, Hajishengallis G. The Complement-Targeted Inhibitor Mini-FH Protects against Experimental Periodontitis via Both C3-Dependent and C3-Independent Mechanisms. (2023). J Immunol. 211(3):453-461. PMID: 37306457

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Penn Today: How One Inflammatory Disorder Exacerbates Another
“The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflammation, it can prove detrimental, perpetuating a misguided immune response.”

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