Porphyromonas gingivalis (shown as a fimbriated reddish rod), exploits complement (depicted in red and white) and subverts leukocytes (in grey) leading to alterations in the amount and composition of the oral commensal microbiota (brown rods). Collectively, these changes disrupt host homeostasis and lead to destructive inflammatory periodontitis (indicated by the reddened/inflamed tissue and osteoclast-mediated bone erosion). Based on our publication in Cell Host Microbe 2011 (PMID: 22036469). Art credit: Matt Briggs.
Porphyromonas gingivalis subverts neutrophils to block phagocytic killing while promoting inflammation. The image depicts this manipulation of neutrophils by P. gingivalis, which provides ‘bystander’ protection to the entire microbial community and perpetuates dysbiotic inflammation. Based on our publication in Cell Host Microbe 2014 (PMID: 24922578). Art credit: Debbie Maizels.
Systemic inflammation due to periodontitis or arthritis is memorized epigenetically by hematopoietic progenitors that give rise to hyper-inflammatory leukocytes that exacerbate both inflammatory diseases. Based on our publication in CELL 2022 (PMID 35483374). Art credit: Katie Vicari.
