Publications

Hajishengallis G, Belibasakis GN. Proceedings of the 3rd international conference on oral mucosal immunity and microbiome. Front Oral Health. 5:1469116. doi: 10.3389/froh.2024.1469116. 2024. PMID: 39346112
Lim JH, Neuwirth A, Chung KJ, Grossklaus S, Soehnlein O, Hajishengallis G, Chavakis T. Formyl peptide receptor 2 regulates dendritic cell metabolism and Th17 cell differentiation during neuroinflammation (2024). Front Immunol 1:15:1354074. PMID: 39148732
Hajishengallis G, Chavakis T. Stroke-induced trained immunity spells bad news for the heart (2024). Cell Res [Online ahead of publication]. PMID: 39164387
Hajishengallis G, Chavakis T. Central trained immunity and its impact on chronic inflammatory and autoimmune diseases. (2024). J Allergy Clin Immunol. 2024 Jun 10:S0091-6749(24)00604-3. Online ahead of print. PMID: 38866209
Kepp KP, Aavitsland P, Ballin M, Balloux F, Baral S, Bardosh K, Bauchner H, Bendavid E, Bhopal R, Blumstein DT, Boffetta P, Bourgeois F, Brufsky A, Collignon PJ, Cripps S, Cristea IA, Curtis N, Djulbegovic B, Faude O, Flacco ME, Guyatt GH, Hajishengallis G, Hemkens LG, Hoffmann T, Joffe AR, Klassen TP, Koletsi D, Kontoyiannis DP, Kuhl E, La Vecchia C, Lallukka T, Lambris J, Levitt M, Makridakis S, Maltezou HC, Manzoli L, Marusic A, Mavragani C, Moher D, Mol BW, Muka T, Naudet F, Noble PW, Nordström A, Nordström P, Pandis N, Papatheodorou S, Patel CJ, Petersen I, Pilz S, Plesnila N, Ponsonby AL, Rivas MA, Saltelli A, Schabus M, Schippers MC, Schünemann H, Solmi M, Stang A, Streeck H, Sturmberg JP, Thabane L, Thombs BD, Tsakris A, Wood SN, Ioannidis JPA. Panel stacking is a threat to consensus statement validity. (2024). J Clin Epidemiol. 2024 Jun 17:111428. Online ahead of print. PMID: 38897481
Sirisereephap K, Surboyo MDC, Rosenkranz AL, Terao Y, Tabeta K, Maeda T, Hajishengallis G, Maekawa T. Protocols for collecting mouse PDL cells and bone marrow cells, differentiation, and data analysis. (2024). STAR Protoc. 2024 Jun 26;5(3):103162. Online ahead of print. PMID: 38935507
Wang H, Divaris K, Pan B, Li X, Jong-Lim JH, Saha G, Barovic M, Giannakou D, Korostoff JM, Bing Y, Sen S, Moss K, Wu D, Beck JD, Ballantyne CM, Natarajan P, North KE, Netea MG, Chavakis T, Hajishengallis G. (2024). Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss. Cell. May 30: S0092-8674(24)00492-6. PMID: 38838669. • Featured in Cell Research Highlight: “Can dental problems be indicative of clonal hematopoiesis?” by Soichi Sano and Kenneth Walsh
Vergadi E, Kolliniati O, Lapi I, Ieronymaki E, Lyroni K, Alexaki VI, Diamantaki E, Vaporidi K, Hatzidaki E, Papadaki HA, Galanakis E, Hajishengallis G, Chavakis T, Tsatsanis C. (2024). An IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life. Nat Commun. 15(1):680. PMID: 38263289
Sirisereephap K, Tamura H, Lim JH, Surboyo MDC, Isono T, Hiyoshi T, Rosenkranz AL, Sato-Yamada Y, Domon H, Ikeda A, Hirose T, Sunazuka T, Yoshiba N, Okada H, Terao Y, Maeda T, Tabeta K, Chavakis T, Hajishengallis G, Maekawa T. (2024). A novel macrolide-Del-1 axis to regenerate bone in old age. iScience. 27(2):108798. PMID: 38261928
Hajishengallis G. Delving into the adytum of the IL-17 defense pathway. (2023). Cell Host Microbe 31(10):1599-1601. PMID: 37827120
Lamont RJ, Hajishengallis G, Koo H. Social networking at the microbiome-host interface. (2023). Infect Immun. 91(9):e0012423. PMID: 37594277
Hajishengallis G, Netea MG, Chavakis T. Innate immune memory, trained immunity and nomenclature clarification. (2023). Nat Immunol. 24(9):1393-1394. PMID: 37620602
Arce M, Rodriguez-Peña M, Espinoza-Arrue J, Godoy RA, Reyes M, Kajikawa T, Greenwell-Wild T, Hajishengallis G, Abusleme L, Moutsopoulos N, Dutzan N. Increased STAT3 Activation in Periodontitis Drives Inflammatory Bone Loss. (2023). J Dent Res. [Online ahead of print]. PMID: 37697911
Mastellos DC, Hajishengallis G, Lambris JD. A guide to complement biology, pathology and therapeutic opportunity. (2023). Nat Rev Immunol. 2024 24(2):118-141. PMID: 37670180
Li X, Wang H, Schmidt CQ, Ferreira VP, Yancopoulou D, Mastellos DC, Lambris JD, Hajishengallis G. The Complement-Targeted Inhibitor Mini-FH Protects against Experimental Periodontitis via Both C3-Dependent and C3-Independent Mechanisms. (2023). J Immunol. 211(3):453-461. PMID: 37306457
Hajishengallis G. Illuminating the oral microbiome and its host interactions: animal models of disease. (2023). FEMS Microbiol Rev. 47(3):fuad018. PMID: 37113021
Hajishengallis G, Lamont RJ, Koo H. Oral polymicrobial communities: Assembly, function, and impact on diseases. (2023). Cell Host Microbe 31(4):528-538. PMID: 36933557
Mitroulis I, Hajishengallis G, Chavakis T. Bone marrow inflammatory memory in cardiometabolic disease and inflammatory comorbidities. (2023). Cardiovasc Res. 2024 119(18):2801-2812. PMID: 36655373
Hajishengallis G, Chavakis T. Mechanisms and Therapeutic Modulation of Neutrophil-Mediated Inflammation. J Dent Res. 101(13):1563-1571 (2022). PMCID: PMC9703529
Uriarte SM & Hajishengallis G. Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation. Immunol Rev. [Online ahead of publication] (2022). PMID: 36271881
Kalafati L, Hatzioannou A, Hajishengallis G, Chavakis T. The role of neutrophils in trained immunity. Immunol Rev. [Online ahead of publication] (2022). PMID: 36190144
Wang H, Ideguchi H, Kajikawa T, Mastellos DC, Lambris JD & Hajishengallis G. Complement Is Required for Microbe-Driven Induction of Th17 and Periodontitis. J Immunol 209:1370-1378 (2022). PMCID: PMC9530003
Hajishengallis G, Chavakis T. Inflammatory memory and comorbidities. Clin Transl Med. 12(7):e984 (2022). PMID: 35839318
Nagasaki K, Gavrilova O, Hajishengallis G, Somerman MJ. Does the RGD region of certain proteins affect metabolic activity? Front. Dent. Med. 3:974862 (2022).
Irwandi RA, Chiesa ST, Hajishengallis G, Papayannopoulos V, Deanfield JE, D'Aiuto F. The Roles of Neutrophils Linking Periodontitis and Atherosclerotic Cardiovascular Diseases. Front Immunol. 13:915081 (2022). PMCID: PMC9300828
Williams DW, Hajishengallis G, Moutsopoulos NM. Regional specification of oral mucosal immunity. Sci Immunol. 7(72):eabp8632 (2022). PMID: 35714199
Li X, Wang H, Yu X, Saha G, Kalafati L, Ioannidis C, Mitroulis I, Netea MG, Chavakis T, Hajishengallis G. Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities. Cell 185:1709-1727.e18 (2022). PMCID: PMC9106933 • Featured in Nature Reviews Immunology: ‘Fired up in the bone marrow' by Yvonne Bordon • Trends in Immunology Spotlight: ‘Inflammatory comorbidities: to train or not to train?’ by Suhas Bobba & Shabaana A. Khader • Nature Immunology Research Highlights: 'HSCs perpetuate inflammation' by Ioana Visan
Hajishengallis G, Li X, Divaris K, Chavakis T. Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities. Periodontol. 2000 89:215-230 (2022). PMCID: PMC9018499
Hajishengallis G. Interconnection of periodontal disease and comorbidities: Evidence mechanisms, and implications. Periodontol. 2000 89:9-18 (2022). PMCID: PMC9018559
Failer T, Amponsah-Offeh M, Neuwirth A, Kourtzelis I, Subramanian P, Mirtschink P, Peitzsch M, Matschke K, Tugtekin SM, Kajikawa T, Li X, Steglich A, Gembardt F, Wegner AC, Hugo C, Hajishengallis G, Chavakis T, Deussen A, Todorov V & Kopaliani I. Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation. J Clin Invest 132(6):e126155 (2022). PMCID: PMC8920341
Belibasakis GN & Hajishengallis G. Frontiers in Oral Mucosal Immunity and the Microbiome. Front. Oral. Health 2:821148. doi: 10.3389/froh.2021.821148 (2022). PMCID: PMC8757874.
Kajikawa T, Mastellos DC, Hasturk H, Kotsakis GA, Yancopoulou D, Lambris JD, Hajishengallis G. C3-targeted host-modulation approaches to oral inflammatory conditions. Semin Immunol. 59:101608 (2022). PMID: 35691883
Yuan G, Fu C, Yang ST, Yuh DY, Hajishengallis G, Yang S. RGS12 Drives Macrophage Activation and Osteoclastogenesis in Periodontitis. J Dent Res 101:448-457 (2022). PMCID: PMC8935576
Chavakis T, Wielockx, Hajishengallis G. Inflammatory Modulation of Hematopoiesis: Linking Trained Immunity and Clonal Hematopoiesis with Chronic Disorders. Ann Rev Physiol 84: 183-207 (2022). PMID: 34614373
Hasturk H, Hajishengallis, G, Lambris JD, Mastellos DC, Yancopoulou D. Phase 2a clinical trial of complement C3 inhibitor AMY-101 in adults with periodontal inflammation. J Clin Invest 131(23):e152973 (2021). PMCID: PMC8631591 • JCI Video
Wang H, Li X, Kajikawa T, Shin J, Lim J-H, Kourtzelis I, Nagai K, Korostoff J, Grossklaus, S, Naumann R, Chavakis T, Hajishengallis G. Stromal cell-derived DEL-1 inhibits Tfh cell activation and inflammatory arthritis. J Clin Invest 131(19):e150578 (2021). PMCID: PMC8483759 • Editor’s pick in JCI This Month: 'Inflammatory arthritis inhibited by stromal cell–derived DEL-1 in mouse models'
Hajishengallis G, Hasturk H, Lambris JD, Apatzidou DA, Belibasakis GN, Bostanci N, Corby PM, Cutler CW, D’Aiuto F, Hajishengallis E, Huber-Lang M, Ioannidou E, Kajikawa T, Kantarci A, Korostoff JM, Kotsakis GA, Maekawa T, Mastellos DC, Moutsopoulos NM, Myneni S, Nagelberg R, Nilsson B, Papapanou PN, Papathanasiou E, Potempa J, Risitano A, Saito A, Sculean A, Stavropoulos A, Teles FR, Tonetti M, Yancopoulou D. C3-targeted therapy in periodontal disease: moving closer to the clinic. Trends Immunol 42:856-864 (2021). PMCID: PMC8487962
Williams DW, Greenwell-Wild T, Brenchley L, Dutzan N, Overmiller A, Sawaya AP, Webb S, Martin D, Hajishengallis G, Divaris K, Morasso M, Haniffa M, Moutsopoulos NM. (2021). Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity. Cell 184(15):4090-4104.e15 (2021). PMCID: PMC8359928
Hajishengallis G & Chavakis T. DEL-1: A potential therapeutic target in inflammatory and autoimmune disease? Exp. Rev. Clin. Immunol 17:549-552 (2021). PMCID:PMC8359928
Hajishengallis G & Lamont RJ. Polymicrobial communities in periodontal disease: Their quasi-organismal nature and dialogue with the host. Periodontology 2000 86:210- 230 (2021). PMCID PMCID: PMC8957750
Ziogas A, Sajib MS, Lim J-H, Alves, TC, Das A, Witt A, Hagag E, Androulaki N, Grossklaus S, Gerlach M, Noll T, Grinenko T, Mirtschink P, Hajishengallis G, Chavakis T, Mikelis CM, Sprott D. Glycolysis is integral to histamine-induced endothelial hyperpermeability. FASEB J. 35:e21425 (2021). PMCID: PMC7909462
Hajishengallis G & Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol 21:426-440 (2021). PMCID: PMC7841384
Hoare A, Wang H, Meethil A, Abusleme L, Hong B-Y, Moutsopoulos NM, Marsh PD, Hajishengallis G, Diaz PI. A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen. ISME J 15:1490-1504 (2021). PMCID: PMC8115154
Teles F, Wang Y, Hajishengallis G, Hasturk H, Marchesan J. Impact of systemic factors in shaping the periodontal microbiome. Periodontol 2000 85:126-160 (2021). PMID: 33226693PMC
Mitroulis I, Hajishengallis G, Chavakis T. Trained Immunity and Cardiometabolic Disease. Arterioscler Thromb Vasc Biol 41:48-54 (2021). PMCID: PMC7769996
Hajishengallis G, Li X, Chavakis T. Immunometabolic control of hematopoiesis. Mol Aspects Med 77: 100923 (2021). PMCID: PMC7904608
Hajishengallis G. Oral bacteria and leaky endothelial junctions in remote extraoral sites. FEBS J. 288:1475-1478 (2021). PMCID: PMC7904955
Kalafati L, Kourtzelis I, Schulte-Schrepping J, Li, X, Hatzioannou A, Grinenko T, Hagag E, Sinha A, Has C, Dietz S, de Jesus Domingues AM, Nati M, Sormendi S, Neuwirth A, Chatzigeorgiou A, Ziogas A, Lesche M, Dahl A, Henry I, Subramanian P, Wielockx B, Murray P, Mirtschink P, Chung K.-J, Schultze JL, Netea MG, Hajishengallis G, Verginis P, Mitroulis I, Chavakis T. Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity. Cell 183:771-785.e12 (2020). PMCID: PMC7599076 *Co-senior authors
Bao K, Li X, Poveda L, Qi, W, Selevsek N, Gumus P, Emingil G, Grossmann J, Diaz PI, Hajishengallis G, Bostanci N, Belibasakis GN. Proteome and Microbiome Mapping of Human Gingival Tissue in Health and Disease. Front Cell Infect Microbiol 10:588155 (2020). PMCID: PMC7566166
Li X, Colamatteo A, Kalafati L, Kajikawa T, Wang H, Lim JH, Bdeir K, Chung KJ, Yu X, Fusco C, Porcellini A, De Simone S, Matarese G, Chavakis T, De Rosa V, Hajishengallis G. The DEL-1-β3 integrin axis promotes regulatory T cell responses during inflammation resolution. J Clin Invest 130:6261-6277 (2020). PMCID:PMC7685741
Nagai K, Ideguchi H, Kajikawa T, Li X, Chavakis T, Cheng J, Messersmith PB, Heber-Katz E, Hajishengallis G. An injectable hydrogel-formulated inhibitor of prolyl- 4-hydroxylase promotes T regulatory cell recruitment and enhances alveolar bone regeneration during resolution of experimental periodontitis. FASEB J 34:13726-13740 (2020). PMCID: PMC7722135
Hajishengallis G. Local destruction from distant action. J Leukoc Biol 108:1033-1035 (2020). PMID: 33405332
Hajishengallis G, Chavakis T, Lambris JD. Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy. Periodontol. 2000 84: 14-34 (2020). PMCID: PMC7457922
Mitroulis I, Kalafati L, Bornhäuser M, Hajishengallis G, Chavakis T. Regulation of the Bone Marrow Niche by Inflammation. Front. 10.3389/fimmu.2020.01540 (2020) PMCID: PMC7396603
Maekawa T, Tamura H, Domon H, Hiyoshi T, Isono T, Yonezawa D, Hayashi N, Takahashi N, Tabeta K, Maeda T, Oda M, Ziogas A, Alexaki VΙ, Chavakis T, Terao Y, Hajishengallis G. Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1. JCI Insight 5:e136706 doi: 10.1172/jci.insight.136706 (2020). PMCID: PMC7455085
Kajikawa T, Wang B, Li X, Wang H, Chavakis T, Moutsopoulos NM, Hajishengallis G. Frontline Science: Activation of metabolic nuclear receptors restores periodontal tissue homeostasis in mice with leukocyte adhesion deficiency-1. J. Leukoc. Biol. 108: 1501-1514 (2020). PMCID: PMC7606738. • Editorial commentary: 'Altruistic death: Neutrophil apoptosis maintains gingival health' by Kelley N Cooper & Juhi Bagaitkar
Yuh D-Y, Maekawa T, Li X, Kajikawa T, Bdeir K, Chavakis T, Hajishengallis G. The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration. J. Biol. Chem. 295:7261- 7273 (2020). PMCID: PMC7247308
Kourtzelis I, Hajishengallis G, Chavakis T. (2020) Phagocytosis of Apoptotic Cells in Resolution of Inflammation. Front. Immunol. 11:553. doi:10.3389/fimmu.2020.00553. PMCID: PMC7137555
Hughes S, Gumas J, Lee R, Romano M, Berger N, Gautam AK, Sfyroera G, Chan AL, Gnanaguru G, Connor KM, Kim BJ, Dunaief JL, Ricklin D, Hajishengallis G, Yancopoulou D, Reis ES, Mastellos DC, Lambris JD. (2020) Prolonged intraocular residence and retinal tissue distribution of a fourth-generation compstatin-based C3 inhibitor in non-human primates. Clin Immunol, 214: article No.108391 (2020). PMCID: PMC7368884
Hajishengallis G & Diaz PI. Porphyromonas gingivalis: Immune Subversion Activities and Role in Periodontal Dysbiosis. Current Oral Health Reports 7:12-21 (2020). PMCID: PMC7747940
Ziogas A, Maekawa T, Wiessner JR, Le TT, Sprott D, Troullinaki M, Neuwirth A, Anastasopoulou V, Grossklaus S, Chung K-J, Sperandio M, Chavakis T, Hajishengallis G, Alexaki VI. DHEA inhibits leukocyte recruitment through regulation of the integrin antagonist DEL-1.* J. Immunol. 204:1214-1224 (2020). Equally contributing senior authors. PMCID: PMC7026770 • Editor’s Choice Science Signaling: 'Steroids make inflamed tissues less sticky'*
Bao K, Li X, Kajikawa T, Toshiharu A, Selevsek N, Grossmann J, Hajishengallis G, Bostanci N. Pressure cycling technology-assisted mass spectrometric quantification of gingival tissue reveals proteome dynamics during the initiation and progression of inflammatory periodontal disease. Proteomics. 20:e1900253. doi: 10.1002/pmic.201900253 (2020). PMCID: PMC7033018
Hajishengallis G. New developments in neutrophil biology and periodontitis. Periodontol 2000. 82:78-92 (2020). PMID: 31850633
Hajishengallis G, Li X, Mitroulis I, Chavakis T. Trained Innate Immunity and Its Implications for Mucosal Immunity and Inflammation. Adv Exp Med Biol. 1197:11-26 (2019). PMCID: PMC6986364
Belibasakis GN & Hajishengallis G. Advances in Oral Mucosal Immunity and the Microbiome. Adv Exp Med Biol. 1197:1-9. doi: 10.1007/978-3-030-28524-1 (2019).
Bostanci N, Abe T, Belibasakis GN, Hajishengallis G. TREM-1 Is Upregulated in Experimental Periodontitis, and Its Blockade Inhibits IL-17A and RANKL Expression and Suppresses Bone Loss. Journal of Clinical Medicine 8:1579 (2019). PMCID: PMC6832657
Mastellos DC, Blom AM, Connolly ES, Daha MR, Geisbrecht BV, Ghebrehiwet B, Gros P, Hajishengallis G, Holers VM, Huber-Lang M, Kinoshita T, Mollnes TE, Montgomery RA, Morgan BP, Nilsson B, Pio R, Ricklin D, Risitano AM, Taylor RP, Mantovani A, Ioannidis JPA, Lambris JD. ‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development. Nat Immunol. Sep 27. doi: 10.1038/s41590-019-0503-1. (2019).
Chavakis T, Mitroulis I, Hajishengallis G. Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation. Nat. Immunol. 20:802-811 (2019). PMCID: PMC6709414
Reis ES, Mastellos DC, Hajishengallis G, Lambris JD. New insights into the immune functions of complement. Nat Rev Immunol. 19: 503–516 (2019). PMCID: PMC6667284
Hajishengallis G, Chavakis T. DEL-1-Regulated Immune Plasticity and Inflammatory Disorders. Trends Mol Med 25: 444-459 (2019). PMCID: PMC6488420
Hajishengallis G, Kajikawa T, Hajishengallis E, Maekawa T, Reis ES, Mastellos DC, Yancopoulou D, Hasturk H, Lambris JD. Complement-Dependent Mechanisms and Interventions in Periodontal Disease. Front Immunol 10:406 doi.org/10.3389/fimmu.2019.00406 (2019). PMCID: PMC6422998
Wang B, Lim JH, Kajikawa T, Li X, Vallance BA, Moutsopoulos NM, Chavakis T, Hajishengallis G. Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis. Cell Rep. 26:1614-1626.e5 (2019). PMCID: PMC6404229
Penkov S, Mitroulis I, Hajishengallis G, Chavakis T. Immunometabolic Crosstalk: An Ancestral Principle of Trained Immunity? Trends Immunol. 40:1-11 (2019). PMCID: PMC6312479
Kourtzelis I, Li X, Mitroulis I, Grosser D, Kajikawa T, Wang B, Grzybek M, von Renesse J, Czogalla A, Troullinaki M, Ferreira A, Doreth C, Ruppova K, Chen LS, Hosur K, Lim JH, Chung KJ, Grossklaus S, Tausche AK, Joosten LAB, Moutsopoulos NM, Wielockx B, Castrillo A, Korostoff JM, Coskun Ü, Hajishengallis G, Chavakis T. DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nat Immunol. 20:40-49 (2019). PMCID: PMC6291356 Co-senior and co-corresponding authors. • Commentary in Nature Immunology: ‘DELineating resolution of inflammation’* by Fredman G. • Saas P and Perruche S: F1000Prime Recommendation of [Kourtzelis I et al., Nat Immunol 2019 20(1):40-49]. In F1000Prime, 15 Feb 2019; 10.3410/f.734462995.793556078
Dutzan N, Kajikawa T, Abusleme L, Greenwell-Wild T, Zuazo CE, Ikeuchi T, Brenchley L, Abe T, Hurabielle C, Martin D, Morell RJ, Freeman AF, Lazarevic V, Trinchieri G, Diaz PI, Holland SM, Belkaid Y, Hajishengallis G, Moutsopoulos NM. A dysbiotic microbiome triggers Th17 cells to mediate oral mucosal immunopathology in mice and humans. Sci. Transl. Med. 10:eaat0797 (2018). PMCID: PMC6330016 *Senior authors.
Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol. 16:745–759 (2018). PMCID: PMC6278837
Reis ES, Berger N, Wang X, Koutsogiannaki S, Doot RK, Gumas JT, Foukas PG, Resuello RRG, Tuplano JV, Kukis D, Tarantal AF, Young AJ, Kajikawa T, Soulika A, Mastellos DC, Yancopoulou D, Biglarnia AR, Huber-Lang M, Hajishengallis G, Nilsson B, Lambris JD. Safety profile after prolonged C3 inhibition. Clin Immunol. 197:96-106 (2018). PMCID: PMC6258316
Bostanci N, Bao K, Xiaofei L, Maekawa T, Grossmann J, Panse C, Briones RA, Resuello RRG, Tuplano JV, Garcia CAG, Reis ES, Lambris JD, Hajishengallis G. Gingival exudatome dynamics implicate inhibition of the alternative complement pathway in the protective action of the C3 inhibitor Cp40 in non-human primate periodontitis. J Proteome Res. 17: 3153–3175 (2018). PMCID: PMC6128774
Kim H, Kajikawa T, Walsh MC, Takegahara N, Jeong YH, Hajishengallis G, Choi Y. The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis. BMB Rep. 51:468-473 (2018). PMCID: PMC6177510
Mitroulis I, Kalafati L, Hajishengallis G, Chavakis T. Myelopoiesis in the Context of Innate Immunity. J Innate Immun. 10:365-372 (2018). PMCID: PMC6281852
Zhang T, Wu J, Ungvijanpunya N, Jackson-Weaver O, Gou Y, Feng J, Ho TV, Shen Y, Liu J, Richard S, Jin J, Hajishengallis G, Chai Y, Xu J. Smad6 methylation represses NFκB activation and periodontal inflammation. J Dent Res. 97:810-819. (2018). PMCID: PMC6728583
Chen LS, Kourtzelis I, Singh RP, Grossklaus S, Wielockx B, Hajishengallis G, Chavakis T, Mitroulis I. Endothelial cell-specific overexpression of DEL-1 drives expansion of hematopoietic progenitor cells in the bone marrow.* Thromb Haemost. 2018 118:613- 616 (2018). PMCID: PMC6081267 *Contributed equally as senior authors.
Mitroulis I, Ruppova K, Wang B, Chen L-S, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, Joosten LAB, Isermann B, Lesche M, Petzold A, Simons K, Henry I, Dahl A, Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun U, Hajishengallis G, Netea MG, Chavakis T. Modulation of myelopoiesis progenitors is an integral component of trained immunity.* Cell. 172:147–161 (2018). PMCID: PMC5766828 Contributed equally as senior authors. • Commentary in Cell: ‘Immune Training Unlocks Innate Potential’* by Song WM & Colonna M. • Commentary in Nat Immunol. 2018 19(4):320-322. doi: 10.1038/s41590-018-0073-7. PMID: 29563630. ‘Training myeloid precursors with fungi, bacteria and chips’ by Kopf M and Nielsen PJ. • Commentary in Cardiovasc Res. 2018 114(6):e41-e42. doi: 10.1093/cvr/cvy043. PMID: 29897493. ‘Trained immunity and cardiovascular disease: is it time for translation to humans?’ by Norata GD.
Hajishengallis G, Reis ES, Mastellos DC, Ricklin D, Lambris JD. Novel mechanisms and functions of complement. Nat. Immunol. 18:1288-1298 (2017). PMCID: PMC5706779
Belibasakis GN, Curtis MA, Hajishengallis G, Zaura E. Meeting report: The 12th European oral microbiology workshop (EOMW) in Stockholm, Sweden. Virulence. 9:64-69 (2018). PMID:28881167
Hajishengallis G, Lamont RJ. Metabolic nuclear receptors in periodontal host-microbe interactions and inflammation. Mol Oral Microbiol. 32:443-445 (2017). PMID: 28984043
Kajikawa T, Briones RA, Resuello RRG, Tuplano JV, Reis ES, Hajishengallis E, Garcia CAG, Yancopoulou D, Lambris JD, Hajishengallis G. Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates. Mol. Ther. Meth. Clin. Dev. 6:207-215 (2017). PMCID: PMC5577415
Mitroulis I, Chen LS, Singh RP, Kourtzelis I, Economopoulou M, Kajikawa T, Troullinaki M, Ziogas A, Ruppova K, Hosur K, Maekawa T, Wang B, Subramanian P, Tonn T, Verginis P, von Bonin M, Wobus M, Bornhäuser M, Grinenko T, Di Scala M, Hidalgo A, Wielockx B, Hajishengallis G, Chavakis T. Secreted protein DEL-1 regulates myelopoiesis in the hematopoietic stem cell niche. J Clin Invest. 127:3624-3639 (2017). PMCID: PMC5617665. *Equal contribution as senior author.
Subramanian P, Prucnal M, Gercken B, Economopoulou M, Hajishengallis G, Chavakis T. Endothelial cell-specific overexpression of developmental endothelial locus-1 does not influence atherosclerosis development in ApoE-/- mice. Thromb Haemost. 117:2003- 2005 (2017). PMCID: PMC5629113
Makkawi H, Hoch S, Burns E, Hosur K, Hajishengallis G, Kirschning CJ, Nussbaum G. Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88. Front Cell Infect Microbiol. 7:359 doi: 10.3389/fcimb.2017.00359 (2017). PMCID: PMC5550410
Hajishengallis G & Korostoff JM. Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later. Periodontol. 2000 75:116-151 (2017). PMCID: PMC5539911
Olsen I, Lambris JD, Hajishengallis G. Porphyromonas gingivalis disturbs host– commensal homeostasis by changing complement function. Journal of Oral Microbiology 9: 1340085. http://dx.doi.org/10.1080/20002297.2017.1340085 (2017). PMCID: PMC5508361
Klotzsche-von Ameln A, Cremer S, Hoffmann J, Schuster P, Khedr S, Korovina I, Troullinaki M, Neuwirth A, Sprott D, Chatzigeorgiou A, Economopoulou M, Orlandi A, Hain A, Zeiher AM, Deussen A, Hajishengallis G, Dimmeler S, Chavakis T, Chavakis E. Endogenous developmental endothelial locus-1 limits ischaemia-related angiogenesis by blocking inflammation. Thromb. Haemost. 117:1150-1163 (2017). PMCID: PMC5502105
Chung KJ, Chatzigeorgiou A, Economopoulou M, Garcia-Martin R, Alexaki VI, Mitroulis I, Nati M, Gebler J, Ziemssen T, Goelz SE, Phieler J, Lim JH, Karalis KP, Papayannopoulou T, Blüher M, Hajishengallis G, Chavakis T. A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity. Nat. Immunol. 18:654- 664 (2017). PMCID: PMC5436941 • Commentary in Nature Reviews Endocrinology: ‘Adipose tissue: Macrophage retention inhibits beige adipogenesis in obesity’ by Holmes D.
Maekawa T, Kulwattanaporn P, Hosur K, Domon H, Oda M, Terao Y, Maeda T, Hajishengallis G. Differential Expression and Roles of Secreted Frizzled-Related Protein 5 and the Wingless Homolog Wnt5a in Periodontitis. J. Dent. Res. 96:571-577 (2017). PMCID: PMC5453495
Moutsopoulos NM, Zerbe CS, Wild T, Dutzan N, Brenchley L, DiPasquale G, Uzel G, Chandler KC, Lisco A, Notarangelo LD, Hajishengallis G, Notarangelo LD, Holland SM. Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1. N. Engl. J. Med. 376:1141-1146 (2017). PMCID: PMC5494261 • Commentary in New England Journal of Medicine: ‘Breaking a Vicious Cycle’ by Klaus Ley. • F1000Prime Recommendation by Zimmerman G and Harris E
Kourtzelis I, Mitroulis I, von Renesse J, Hajishengallis G, Chavakis T. From leukocyte recruitment to resolution of inflammation: the cardinal role of integrins. J Leukoc Biol. 102:677-683 (2017). PMCID: PMC5557641
Kajikawa T, Meshikhes F, Maekawa T, Hajishengallis E, Hosur KB, Abe T, Moss K, Chavakis T, Hajishengallis G. Milk fat globule epidermal growth factor 8 inhibits periodontitis in non-human primates and its gingival crevicular fluid levels can differentiate periodontal health from disease in humans. J Clin Periodontol. 44:472-483. (2017). PMCID: PMC5433891
Hajishengallis G, Krauss JL, Jotwani R, Lambris JD. Differential capacity for complement receptor-mediated immune evasion by Porphyromonas gingivalis depending on the type of innate leukocyte. Mol Oral Microbiol. 32:154-165 (2017). PMCID: PMC5065733
Lee CH, Hajishengallis G, Connell TD. Dendritic cell-mediated mechanisms triggered by LT-IIa-B5, a mucosal adjuvant derived from a type II heat-labile enterotoxin of Escherichia coli. J. Microbiol. Biotechnol. 27(4):709-717 (2017) PMCID: PMC5418089
El-Kassas S, Odemuyiwa S, Hajishengallis G, Connell TD, Nashar TO. Expression and Regulation of Cholecystokinin Receptor in the Chicken’s Immune Organs and Cells. J Clin Cell Immunol. 7: 471. doi: 10.4172/2155-9899.1000471 (2016). PMCID: PMC5279896
Hajishengallis G & Lambris JD. More than complementing Tolls: Complement–Toll-like receptor synergy and crosstalk in innate immunity and inflammation. Immunol. Rev. 274:233-244 (2016). PMCID: PMC5119927
Mastellos DC, Reis ES, Yancopoulou D, Hajishengallis G, Ricklin D, Lambris JD. From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage. Immunobiology. 221:1046-1057 (2016) PMCID: PMC4987232
Olsen I & Hajishengallis G. Major neutrophil functions subverted by Porphyromonas gingivalis. J Oral Microbiol. 8:30936. doi: 10.3402/jom.v8.30936 (2016). PMCID: PMC4799392
Hajishengallis G, Hajishengallis E, Kajikawa T, Wang B, Yancopoulou D, Ricklin D, Lambris JD. Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application. Sem Immunol 28:285-289 (2016). PMCID: PMC4987193
Hajishengallis G & Lamont RJ. Dancing with the Stars: how Choreographed Bacterial Interactions Dictate Nososymbiocity and Give Rise to Keystone Pathogens, Accessory Pathogens, and Pathobionts. Trends Microbiol. 24:477-489 (2016). PMCID: PMC4874887
Hajishengallis G, Moutsopoulos NM, Hajishengallis E, Chavakis T. Immune and regulatory functions of neutrophils in inflammatory bone loss. Semin Immunol. 28:146- 158 (2016). PMCID: PMC4867283
Maekawa T, Briones RA, Resuello RR, Tuplano JV, Hajishengallis E, Kajikawa T, Koutsogiannaki S, Garcia CA, Ricklin D, Lambris JD, Hajishengallis G. Inhibition of pre- existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3. J. Clin. Periodontol. 43: 238-249 (2016). PMCID: PMC4803614
Hajishengallis G & Moutsopoulos NM. Role of bacteria in leukocyte adhesion deficiency- associated periodontitis. Microb Pathog. 94: 21-26 (2016). PMCID: PMC4791199
Mastellos DC, Ricklin D, Hajishengallis E, Hajishengallis G, Lambris JD. Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention. Mol Oral Microbiol. 31: 3-17 (2016). PMCID: PMC4712080
Duan X, Gleason RC, Li F, Hosur KB, Duan X, Huang D, Wang H, Hajishengallis G, Liang S. Sex dimorphism in periodontitis in animal models. J Periodontal Res. 51(2):196-202 (2016). PMCID: PMC4723298
Kourtzelis I, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, Chavakis T. Developmental endothelial locus-1 modulates platelet- monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thromb Haemost. 115:781-788. (2016). PMCID: PMC4818166
Subramanian P, Mitroulis I, Hajishengallis G, Chavakis T. Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors. Curr Opin Hematol. 23:36-43 (2016) PMCID: PMC4668230.
Hajishengallis G & Korostoff JM. Response to Comment on "The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis". J Immunol. 195:5099- 100 (2015) PMID:26589744.
Shin J, Maekawa T, Abe T, Hajishengallis E, Hosur K, Pyaram K, Mitroulis I, Chavakis T, Hajishengallis G. DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates. Science Transl Med, 7:307ra155 (2015). PMCID: PMC459306.
Maekawa T, Hosur K, Abe T, Kantarci A, Ziogas A, Wang B, Van Dyke TE, Chavakis T, Hajishengallis G. Antagonistic effects of IL-17 and D-resolvins on endothelial DEL-1 expression through a GSK-3β–C/EBPβ pathway. Nature Communications, 6:8272 (2015). PMCID: PMC4573473
Zenobia C & Hajishengallis G. Basic biology and role of IL-17 in immunity and inflammation. Periodontol. 2000. 69:142-159 (2015). PMCID: PMC4530463
Hajishengallis G, Maekawa T, Abe T, Hajishengallis E, Lambris JD. Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches. Adv Exp Med Biol. 865:57-74 (2015). PMCID: PMC4562417
Abe T, AlSarhan M, Benakanakere MR, Maekawa T, Kinane DF, Cancro MP, Korostoff JM, Hajishengallis G. The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis. J Immunol. 95:1427-1435 (2015) PMCID: PMC4530049
Kim PD, Xia-Juan X, Crump KE, Abe T, Hajishengallis G, and Sahingur SE. Toll-Like Receptor 9-mediated inflammation triggers alveolar bone loss in experimental murine periodontitis. Infect Immun. 83:2992-3002 (2015). PMCID: PMC4468549
Moutsopoulos NM, Lionakis MS, Hajishengallis G. Inborn Errors in Immunity: Unique Natural Models to Dissect Oral Immunity. J Dent Res. 94:753-758 (2015) PMCID: PMC4485330
El-Kassas S, Faraj R, Martin K, Hajishengallis G, Connell TD, Nashar T. Cell Clustering and Delay/Arrest in T-Cell Division Implicate A Novel Mechanism of Immune Modulation by E. coli Heat-Labile Enterotoxin B-Subunits. Cell Immunol. 295:150-162 (2015). PMCID: PMC4439354
Mastellos DC, Yancopoulou D, Kokkinos P, Huber-Lang M, Hajishengallis G, Biglarnia AR, Lupu F, Nilsson B, Risitano AM, Ricklin D, Lambris JD. Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention. Eur J Clin Invest. 45:423-440 (2015). PMCID: PMC4380746 • Ghebrehiwet B: F1000Prime Recommendation of [Mastellos DC et al., Eur J Clin Invest 2015 45(4):423-440]. In F1000Prime, 30 Nov 2016; 10.3410/f.725355373.793525823
Hajishengallis, G. Periodontitis: from microbial immune subversion to systemic inflammation. Nature Rev. Immunol. 15: 30-44 (2015) PMCID: PMC4276050
Hu JC, Mathias-Santos C, Greene CJ, King-Lyons ND, Rodrigues JF, Hajishengallis G, Ferreira LCS, Connell TD. Intradermal administration of the type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and cellular immunity to a co-administered antigen. PLOS One (2014) 9(12):e113978. doi: 10.1371/journal.pone.0113978. PMCID: PMC4275187
Zenobia C & Hajishengallis G. Porphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosis. Virulence. 6:236-243 (2015). PMCID: PMC4601496
Hajishengallis G, Lamont RJ, Graves DT. The enduring importance of animal models in understanding periodontal disease. Virulence. 6:229-235 (2015). PMCID: PMC4601315
Lamont RJ & Hajishengallis G. Polymicrobial synergy and dysbiotic inflammation. Trends Transl. Med. 21:172-183 (2015) PMCID: PMC4352384.
Hajishengallis G, Chavakis T, Hajishengallis E, Lambris JD. Neutrophil homeostasis and inflammation: novel paradigms from studying periodontitis J. Leukoc. Biol. 98:539-48 (2015) PMCID: PMC4569046
Mitroulis I, Alexaki VI, Kourtzelis I, Ziogas A, Hajishengallis G, Chavakis T. Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease. Pharmacol Ther. 147C:123-135 (2015) PMCID: PMC4324083
Choi EY, Lim JH, Neuwirth A, Economopoulou M, Chatzigeorgiou A, Chung KJ, Bittner S, Lee SH, Langer H, Samus M, Kim H, Cho GS, Ziemssen T, Bdeir K, Chavakis E, Koh JY, Boon L, Hosur K, Bornstein SR, Meuth SG, Hajishengallis G, Chavakis T. Developmental endothelial locus-1 (DEL-1) is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination. Mol. Psychiatry. 20: 880-888 (2015). PMCID: PMC4351922.
Hajishengallis, G. MFG-E8, a novel homeostatic regulator of osteoclastogenesis Inflamm Cell Signal. 1: e285. doi: 10.14800/ics.285 (2014).
Hajishengallis G. The inflammophilic character of the periodontitis-associated microbiota. Mol. Oral Microbiol. 29:248-257 (2014). PMCID: PMC4232466
Hajishengallis G & Moutsopoulos NM. Etiology of leukocyte adhesion deficiency- associated periodontitis revisited: Not a raging infection but a raging inflammatory response. Exp. Rev. Clin. Immunol. 10:973-975 (2014). PMCID: PMC4117468
Abe T, Shin J, Hosur KB, Udey MC, Chavakis T, Hajishengallis G. Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8 J. Immunol. 193:1383-1391 (2014). PMCID: PMC4108495
Maekawa T, Krauss JL, Abe T, Jotwani R, Triantafilou M, Triantafilou K, Hashim A, Hoch S, Curtis MA, Nussbaum G, Lambris JD, Hajishengallis G. Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis. Cell Host Microbe 15: 768–778 (2014). PMCID: PMC4071223 • Featured in Nature Reviews Immunology: ‘Mucosal immunology: two routes to success’ by Rachel David • Featured in Trends Microbiol. 2014 22(8):428-9. doi: 10.1016/j.tim.2014.06.006. PMID: 25001854. ‘Porphyromonas gingivalis neutrophil manipulation: risk factor for periodontitis?’ by Darveau RP. • Featured in Scientific American: ‘Gingivitis Bacteria Triggers a Tailspin in Your Mouth: In small numbers a keystone pathogen can still cause destruction’ by Diana Crow
Maekawa T, Abe T, Hajishengallis E, Hosur KB, DeAngelis RA, Ricklin D, Lambris JD, Hajishengallis G. Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis. J. Immunol. 192:6020-6027 (2014). PMCID: PMC4078411 • Featured in ‘In This Issue’ J Immunol June 15, 2014, 192 (12) 5445-5446 •6ABC ActionNews Segment
Hajishengallis G & Sahingur SE. Novel biological mechanisms in periodontitis. Adv. Dent. Res. 26:23-29 (2014). PMCID: PMC6636229
Moutsopoulos N, Konkel J, Sarmadi M, Eskan MA, Wild T, Dutzan N, Abusleme L, Zenobia C, Hosur KB, Abe T, Uzel G, Chen W, Chavakis T, Holland SM, Hajishengallis G. Defective neutrophil recruitment in leukocyte adhesion deficiency Type I disease causes local IL-17–driven inflammatory bone loss. Science Transl. Med. 6:229ra40 (2014). PMCID: PMC4090608 • Featured in Nature Reviews Immunology: Disrupting the 'neutrostat' in LAD-I by Kirsty Minton • Featured in Science–Business eXchange. Vol. 7, pg. 13 • Highlighted in British Dental Journal Vol. 216 No. 12, pg 657 JUN 27 2014
Hajishengallis G & Lamont RJ. Breaking bad: Manipulation of the host response by Porphyromonas gingivalis. Eur. J. Immunol. 44:328-338 (2014). PMCID: PMC3925422
Maekawa T & Hajishengallis G. Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss. J. Periodont. Res. 49:785-791 (2014). PMCID: PMC4119090
Dinasarapu AS, Chandrasekhar A, Hajishengallis G & Subramaniam S. Integrin beta-2 (human). UCSD Molecule Pages doi:10.6072/H0.MP.A004263.01 (2013).
Hajishengallis, G. Immunomicrobial pathogenesis of periodontitis: Keystones, pathobionts, and host response. Trends Immunol. 35:3-11 (2014). PMCID: PMC3947349
Mitroulis, I, Kang YY, Gahmberg CG, Siegert G, Hajishengallis G, Chavakis T, Choi E-Y. Developmental endothelial locus–1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin. Thromb. Haemost. 111:1004-1006 (2014). PMCID: PMC4013214
Shin J, Hosur KB, Pyaram K, Jotwani R, Liang S, Chavakis T, Hajishengallis G. Expression and function of the homeostatic molecule DEL-1 in endothelial cells and the periodontal tissue. Clin. Dev. Immunol. 2013:articleID 617809, http://dx.doi.org/10.1155/2013/617809 (2013). PMCID: PMC3876683
Hajishengallis E & G. Hajishengallis. Neutrophil homeostasis and its impact on periodontal health in children and adults. J. Dent. Res. 93:231-237 (2014). PMCID: PMC3929973
Hajishengallis G. Aging and its impact on innate immunity and inflammation: Implications for periodontitis. J. Oral Biosci. 56: 30–37 (2014). PMCID: PMC3974203
Hajishengallis, G, Mantovani A, Moretta A, Lambris JD. Aegean reflections on innate immunity. Nat. Immunol. 14:1025-1029 (2013). PMID: 24048131
Hajishengallis G, Abe T, Maekawa T, Hajishengallis E, Lambris JD. Role of complement in host-microbe homeostasis of the periodontium. Sem. Immunol. 25: 65– 72 (2013). PMCID: PMC3706506
Abe T & Hajishengallis G. Optimization of the ligature-induced periodontitis model in mice. J Immunol. Meth. 394: 49–54 (2013). PMCID: PMC3707981
Zenobia C, Luo XL, Hashim A, Abe T, Jin L, Chang Y, Jin ZC, Sun JX, Hajishengallis G, Curtis MA, and Darveau RP. Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis. Cell. Microbiol. 15:1419-1426 (2013) PMCID: PMC3711967
Hajishengallis G & Connell TD. Type II heat-labile enterotoxins: Structure, function, and immunomodulatory properties. Vet. Immunopathol. 152: 68-77 (2013). PMCID: PMC3572302.
Hajishengallis G, McIntosh ML, Nishiyama S-I, Yoshimura F. Mechanism and implications of CXCR4-mediated integrin activation by Porphyromonas gingivalis. Mol. Oral Microbiol. 28:239-249 (2013). PMCID: PMC4123224
Hajishengallis G & Chavakis T. Endogenous modulators of inflammatory leukocyte recruitment. Trends Immunol. 34:1-6 (2013). PMCID: PMC3703146
Hajishengallis G. A Toll gate to escape T cells. J. Leukoc. Biol. 93:3-5 (2013). PMID: 23284089
Hajishengallis G & Lambris JD. Complement-targeted therapeutics in periodontitis. Adv. Exp. Med. Biol. 734:197-206 (2013). PMCID: PMC3466049
Abe T, Hosur KB, Hajishengallis E, Reis ES, Ricklin D, Lambris JD, Hajishengallis G. Local complement-targeted intervention in periodontitis: Proof-of-concept using a C5a receptor (CD88) antagonist. J. Immunol. 189:5442-5448 (2012). PMCID: PMC3504137 • Featured in “In This Issue”; J Immunol December 1, 2012, 189 (11) 5095-5096 • Featured in ImmunoCast and “In This Issue”; Journal of Immunology Dec. 1, 2012 • Featured on The Jackson Laboratory website, Jan. 3, 2013: "Complement Blocker Mitigates Periodontitis in Mice"
Hajishengallis G & Lambris JD. Complement and dysbiosis in periodontal disease. Immunobiol. 217:1111-1116 (2012). PMCID: PMC3439646
Cody V, Pace J, Nawar HF, King-Lyons N, Liang S, Connell TD & Hajishengallis G. Structure-activity correlations of mutant forms of the B pentamer of Escherichia coli Type II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding. Acta Cryst. D68:1604–1612 (2012). PMCID: PMC3498930
Hajishengallis G & Lamont RJ. Beyond the red complex and into more complexity: The polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol. Oral Microbiol. 27:409-419 (2012). PMCID: PMC3653317
Hajishengallis G, Darveau RP & Curtis MA. The keystone-pathogen hypothesis. Nat. Rev. Microbiol. 10:717-725 (2012). PMCID: PMC3498498
McIntosh ML & Hajishengallis, G. Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment. Mol. Oral Microbiol. 27:449–457 (2012). PMCID: PMC3494490
Darveau RP, Hajishengallis G., Darveau RP & Curtis MA. Porphyromonas gingivalis as a potential community activist for disease. J. Dent. Res. 91:816-820 (2012). PMCID: PMC3420389
Eskan MA, Jotwani R, Abe T, Chmelar J, Lim J-H, Liang S, Ciero PA, Krauss JL, Li F, Rauner M, Hofbauer LC, Choi EY, Chung K-J, Hashim A, Curtis MA, Chavakis T & Hajishengallis G. The leukocyte integrin antagonist DEL-1 inhibits IL-17-mediated inflammatory bone loss. Nat. Immunol., 13: 465-473 (2012). PMCID: PMC3330141 • Commentary in Nature Immunology: ‘Restraining IL-17: DEL-1 deals the blow’ by Khader SA • Featured in Science–Business eXchange, “DEL1: taking the bite out of periodontitis” SciBX 5(15); doi:10.1038/scibx.2012.381
Hajishengallis G, Krauss JL, Liang S, McIntosh MJ & Lambris JD. Pathogenic microbes and community service through manipulation of innate immunity. Adv. Exp. Med. Biol. 946:69-85 (2012). PMCID: PMC3214273
Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, McIntosh ML, Alsam A, Kirkwood KL, Lambris JD, Darveau RP & Curtis MA. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host & Microbe, 10:497-506 (2011). PMCID: PMC3221781 • Commentary in Cell Host Microbe, 10:423-5, 2011, PMID: 22100158, ‘Porphyromonas gingivalis Sinks Teeth into the Oral Microbiota and Periodontal Disease’ by Kenya Honda. • Featured in Nature Reviews Microbiology ‘Highlights’ section: 2011 10(1):3. doi:10.1038/nrmicro2723. PMID: 22173555. ‘Microbiome: Tipping the balance’ by Sheilagh Molloy. • F1000Prime Recommendation by Gaffen S and Conti H
Lee CH, Masso-Welch P, Hajishengallis G, Connell TD. TLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin. J. Leukoc. Biol., 90:911-921 (2011). PMCID: PMC3206473
Hajishengallis G. Immune evasion strategies of Porphyromonas gingivalis. J. Oral Biosci. 53:233-240 (2011). PMCID: PMC3231999
Liang S, Krauss JL, Domon H, McIntosh ML, Hosur KB, Qu H, Li F, Tzekou A, Lambris JD, Hajishengallis G. The C5a receptor impairs IL-12–dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J. Immunol. 186:869-877 (2011). PMCID: PMC3075594
Hajishengallis G & Lambris JD. Microbial manipulation of receptor crosstalk in innate immunity. Nature Rev. Immunol. 11: 187-200 (2011). PMCID: PMC3077082
Brown J, Wang H, Hajishengallis G & Martin M. TLR-signaling networks: An integration of adaptor molecules, kinases, and cross-talk. J Dent. Res. 90:417-427 (2011) PMCID: PMC3075579
Nawar HF, Greene CJ, Lee CH, Mandel L, Hajishengallis G & Connell TD. LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb. Vaccine 29:721-727 (2011). PMCID: PMC3035162
Hajishengallis G & Lambris JD. Illuminating the latest advances in innate immunity in the island of the sun god. Exp. Rev. Clin. Immunol. 6:875-878 (2010). PMID: 20979552
Ricklin D, Yang K, Hajishengallis G, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11:785-97 (2010). PMCID: PMC2924908
Hajishengallis G. Complement and Periodontitis. Biochem Pharmacol. 80:1992-2001 (2010). PMCID: PMC2955993
Nawar HF, Berenson CS, Hajishengallis G, Takematsu H, Mandell L, Clare RL, Connell TD. Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the non-toxic mucosal adjuvant LT- IIb(T13I). Clin. Vaccine Immunol 17:969-978 (2010). PMCID: PMC2884423
Lee CH, Nawar HF, Mandel L, Liang S, Hajishengallis G, Connell TD. Enhanced antigen uptake by dendritic cells induced by the B pentamer of the type II heat-labile enterotoxin LT-IIa requires engagement of TLR2. Vaccine 28:3696-3705 (2010). PMCID: PMC2862118
Wang M, Krauss JL, Domon H, Hosur KB, Liang S, Magotti P, Triantafilou K, Lambris JD, Hajishengallis G. Microbial hijacking of complement–Toll-like receptor crosstalk. Science Signaling 3:ra11 (2010). PMCID: PMC2824906 • Commentary in Sci Signal 3(120):pe15 (2010) doi: 10.1126/scisignal.3120pe15, ‘Complementing Toll signaling’ by Jonathan C Kagan • F1000Prime Recommendation by Sarah L Gaffen • Featured in the on-line cover and in podcast (Science Signaling. 2010 Feb 16;3[109]:pc4) • Featured in a commentary (Kagan JC, 2010, Sci. Signal., 3:pe15) • Featured in the International Complement Society Newsletter (6/20100)
Liang S, Hosur KB, Domon H, Hajishengallis G. Periodontal inflammation and bone loss in aged mice. J. Periodont. Res. 45:574-578 (2010). PMCID: PMC2894296
Hajishengallis G & Lambris JD. Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol. 31:154-163 (2010). PMCID: PMC2849859
Liang S & Hajishengallis G. Heat-labile enterotoxins as adjuvants or anti-inflammatory agents. Immunol. Invest. 39:449-467 (2010). PMCID: PMC2819675
Hajishengallis G. Too old to fight? Aging and its toll on innate immunity. Mol. Oral Microbiol. 25:25-37 (2010). PMCID: PMC2839454
Berenson CS, Nawar HF, Yohe HC, Ashline D, Castle S, Reinhold VN, Hajishengallis G & Connell TD. Mammalian cell ganglioside-binding specificities of E. coli enterotoxins LT-IIb and variant LT-IIb(T13I). Glycobiology 20:41-54 (2010). PMCID: PMC2782182
Krauss J, Potempa J, Lambris JD, Hajishengallis G. Complementary Tolls in the periodontium: How periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontol. 2000 52:141-162 (2010). PMCID: PMC2796596.
Wang M, Liang S, Hosur KB, Domon H, Yoshimura F, Amano A, Hajishengallis G. Differential virulence and innate immune interactions of Type I and II fimbrial genotypes of Porphyromonas gingivalis. Oral Microbiol. Immunol. 24: 478–484 (2009). PMCID: PMC2883777
Liang S, Domon H, Hosur KB, Wang M, Hajishengallis G. Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro. Mech. Ageing Dev. 130:538-546 (2009). PMCID: PMC2717634
Pierce DL, Nishiyama S-I, Wang M, Liang S, Triantafilou M, Triantafilou K, Yoshimura F, Demuth DR & Hajishengallis G. Host adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis. Infect. Immun. 77:3294–3301 (2009). PMCID: PMC2715668
Liang S, Hosur KB, Nawar HF, Russell MW, Connell TD, Hajishengallis G. In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT- IIb-B5) from Escherichia coli. Vaccine 27:4302-4308 (2009). PMCID: PMC2700856
Hajishengallis G. Porphyromonas gingivalis-host interactions: Open war or intelligent guerilla tactics? Microb. Infect. 11:637-645 (2009). PMCID: PMC2704251 • Characterized as a high-impact review in cellular microbiology by the editors (Ojcius D.M. and S.H.E. Kaufmann, 2010, Microbes and Infection: Past, present and future. Microb Infect 12:1-2)
Hajishengallis G, Wang M, Liang S. Induction of distinct Toll-like receptor 2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae. J. Immunol. 182:6690-6696 (2009). PMCID: PMC2685460
Hajishengallis G. Toll gates to periodontal host modulation and vaccine therapy. Periodontol. 2000 51:181-207 (2009). PMCID: PMC2775135
Kinane DF & Hajishengallis G. Polymicrobial infections, biofilms, and beyond (invited editorial). J. Clin. Periodontol. 36:404–405 (2009).
Liang S, Hosur KB, Lu S, Nawar HF, Weber BR, Tapping RI, Connell TD, Hajishengallis G. Mapping of a microbial protein domain involved in binding and activation of the TLR2/TLR1 heterodimer. J. Immunol. 182:2978-2985 (2009). PMCID: PMC2648068
Hajishengallis G, Wang M, Liang S, Triantafilou M, Triantafilou K. Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function. Proc. Natl. Acad. Sci. USA 105:13532-13537(2008). PMCID: PMC2533224 • Highlighted in the Editor’s Choice section of the AAAS/Science Signaling (N. R. Gough, Promoting an Inactivating Partnership. Sci. Signal. 1 (37), ec323. [DOI: 10.1126/scisignal.137ec323]. • Commentary in Future Microbiology, ‘Priority Paper Evaluation’ section (Vol. 4, p. 155-157, 2009). ‘Bacteria modulate host-cell responses by capitalizing on the lipid raft structure’ by Richard P. Darveau. • Featured (10/7/08) in a podcast by the Science editors, Nancy R. Gough and John F. Foley (Sci. Signal. 1 (40), pc9 [PMID: 18840876]. • Evaluated in a commentary by Richard P. Darveau in Future Microbiology, ‘Priority Paper Evaluation’ section (Vol. 4, p. 155-157, 2009).
Hajishengallis G, Wang M, Bagby GJ, Nelson S. Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice. J. Immunol 181:4141-4149 (2008). PMCID: PMC2625304
Hajishengallis G, Wang M, Liang S, Shakhatreh MA, James D, Nishiyama S-I, Yoshimura F, Demuth DR. Subversion of innate immunity by periodontopathic bacteria through exploitation of complement receptor-3. Adv. Exp. Med. Biol. 632:203- 219 (2008). PMCID: PMC2649712
Gaffen SL & Hajishengallis G. A new inflammatory cytokine on the block: Re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17. Critical Review in Oral Biology and Medicine Section. J. Dent. Res. 87:817-828 (2008). PMCID: PMC2692983
Wang M & Hajishengallis G. Lipid raft-dependent uptake, signaling, and intracellular fate of Porphyromonas gingivalis in mouse macrophages. Cell. Microbiol. 10:2029-2042 (2008). PMCID: PMC2670473
Graves DT, Fine D, Y.-T., A Teng, Van Dyke TE, Hajishengallis G. The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J. Clin. Periodontol. 35:89-105 (2008). PMCID: PMC2649707
Onishi S, Honma K, Liang S, Stathopoulou P, Kinane DF, Hajishengallis G, Sharma A. TLR2-mediated epithelial cell activation by the Tannerella forsythia leucine-rich repeat BspA protein. Infect. Immun. 76:198-205 (2008). PMCID: PMC2223669
Hajishengallis G, Shakhatreh MA, Wang M, Liang S. Complement receptor-3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo. J. Immunol. 179:2359-2367 (2007). PMID: 17675497
Wang M, Shakhatreh MA, James D, Liang S, Nishiyama S-I, Yoshimura F, Demuth DR, Hajishengallis G. Fimbrial proteins of Porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor-3 to persist in macrophages. J. Immunol. 179:2349-2358 (2007). PMID: 17675496
Hajishengallis G & Harokopakis E. Porphyromonas gingivalis interactions with complement receptor 3 (CR3): Innate immunity or immune evasion? Front. Biosci. 12:4547-4557 (2007).
Kinane DF, Demuth DR, Gorr SU, Hajishengallis G, Martin MH. Human variability in innate immunity. Periodontol. 2000 45:14-34 (2007). PMID: 17850446
Triantafilou M, Gamper FGJ, Lepper PM, Mouratis MA, Schumann C, Harokopakis,Schifferle RE, Hajishengallis G, Triantafilou K. Lipopolysaccharides from atherosclerosis-associated bacteria antagonize TLR4, induce formation of TLR2/1/CD36 complexes in lipid rafts and trigger TLR2-induced inflammatory responses in human vascular endothelial cells. Cell. Microbiol. 9:2030-2039 (2007).
Liang S, Wang M, Triantafilou K, Triantafilou M, Nawar HF, Russell MW, Connell TD, Hajishengallis G. The A subunit of Type IIb enterotoxin (LT-IIb) suppresses the proinflammatory potential of the B subunit and its ability to recruit and interact with TLR2. J. Immunol. 178: 4811-4819 (2007).
Liang, S, Wang M, Tapping RI, Stepensky V, Nawar HF, Triantafilou M, Triantafilou K, Connell TD, Hajishengallis G. Ganglioside GD1a is an essential coreceptor for Toll- like receptor 2 signaling in response to the B subunit of Type IIb enterotoxin. J. Biol. Chem. 282: 7532-7542 (2007).
Hajishengallis G. Peptide mapping of a versatile fimbrial adhesin from Porphyromonas gingivalis. Int. J. Pept. Res. Ther. 13:533-546 (2007).
Hajishengallis G. Potential for immunological and microbiological intervention against Porphyromonas gingivalis infection. doi:10.2330/joralbiosci.49.1, J. Oral Biosci. 49:1-14 (2007).
Eskan MA, Hajishengallis G, Kinane DF. Differential activation of human gingival epithelial cells and monocytes by Porphyromonas gingivalis fimbriae. Infect. Immun. 75:892-898 (2007).
Hajishengallis G, Wang M, Harokopakis E, Triantafilou M, Triantafilou K. Porphyromonas gingivalis fimbriae proactively modulate β2 integrin adhesive activity and promote binding to and internalization by macrophages. Infect. Immun. 74:5558- 5666 (2006).
Harokopakis E, Albzreh MH, Martin MH, Hajishengallis G. TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae. J. Immunol. 176:7645-7656 (2006). • Featured in ‘In This Issue’ highlights of the Journal of Immunology (176: 7141- 7142, 2006).
Hajishengallis G, Tapping RI, Harokopakis E, Nishiyama S-I, Ratti P, Schifferle RE, Lyle EA, Triantafilou M, Triantafilou K, Yoshimura F. Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centered pattern recognition apparatus. Cell. Microbiol. 8:1557-1570 (2006).
Salam MA, J. Katz, Zhang P, Hajishengallis G, Michalek SM. Immunogenicity of Salmonella vector vaccines expressing SBR of Streptococcus mutans under the control of a T7-nirB (dual) promoter system. Vaccine 24:5003–5015 (2006)
Harokopakis E, Albzreh MH, Haase EM, Scannapieco FA, Hajishengallis G. Inhibition of proinflammatory activities of major periodontal pathogens by aqueous extracts from elder flower (Sambucus nigra). J. Periodontol. 77:271-279 (2006).
Hajishengallis, G, Arce S, Gockel CM, Connell TD, Russell MW. Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance: Applications for oral Infections. Critical Review in Oral Biology and Medicine Section. J. Dent. Res. 84:1104-1116 (2005).
Hajishengallis G, Ratti P, Harokopakis E. Peptide mapping of bacterial fimbrial epitopes interacting with pattern-recognition receptors. J. Biol. Chem. 280: 38902 – 38913 (2005).
Harokopakis E & Hajishengallis G. Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like Receptor 2, and phosphatidylinositol-3-kinase. Eur. J. Immunol. 35:1201-1210 (2005).
Hajishengallis G, Tapping RI, Martin MH, Nawar H, Lyle EA, Russell MW, Connell TD. Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxins. Infect. Immun. 73:1343-1349 (2005).
Hajishengallis G, Nawar H, Tapping RI, Russell MW, Connell TD. The type II heat- labile enterotoxins (LT-IIa and LT-IIb) and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells. Infect. Immun. 72: 6351-6358 (2004).
Hajishengallis G, Sojar H, Genco RJ, DeNardin E. Intracellular signaling and cytokine induction upon interactions of Porphyromonas gingivalis fimbriae with pattern- recognition receptors. Immunol. Invest. 33: 157-172 (2004).
Hajishengallis G & Genco RJ. Downregulation of the DNA-binding activity of nuclear Factor-κB p65 subunit in Porphyromonas gingivalis fimbria-induced tolerance. Infect. Immun. 72: 1188-1191 (2004).
Hajishengallis G, Sharma A, Russell MW, Genco RJ. Interactions of oral pathogens with Toll-like receptors: Possible role in atherosclerosis. Annals Periodontol. 7:72-78 (2002).
Zhang P, Jespersgaard C, Lamberty-Mallory L, Katz J, Huang Y, Hajishengallis G, Michalek SM. Enhanced immunogenicity of a genetic chimeric protein consisting of two virulence antigens of Streptococcus mutans and protection against infection. Infect. Immun. 70: 6779-6787 (2002).
Hajishengallis G, Martin M, Schifferle RE, Genco RJ. Counteracting interactions between lipopolysaccharide molecules with differential activation of Toll-like receptors. Infect. Immun. 70: 6658-6664 (2002).
Hajishengallis G, Martin M, Sojar HT, Sharma A, Schifferle RE, DeNardin E, Russell MW, Genco RJ. Dependence of bacterial protein adhesins on Toll-like receptors for proinflammatory cytokine induction. Clin. Diag. Lab. Immunol. 9:403-411 (2002).
Jespersgaard C, Hajishengallis G, Russell MW, Michalek SM. Identification and characterization of a nonimmunoglobulin factor in human saliva that inhibits Streptococcus mutans glucosyltransferase. Infect. Immun. 70:1136-1142 (2002).
Jespersgaard C, Zhang P, Hajishengallis G, Russell MW, Michalek SM. Effect of attenuated Salnonella enterica serovar Typhimurium expressing a Streptococcus mutans antigen on secondary responses to the cloned antigen. Infect. Immun. 69: 6604-6611 (2001).
Huang Y, Hajishengallis G, Michalek SM. Induction of protective immunity against Streptococcus mutans colonization after mucosal immunization with attenuated Salmonella enterica serovar Typhimurium expressing a S. mutans adhesin under the control of in vivo-inducible nirB promoter. Infect. Immun. 69:2154-2161. (2001).
Martin M, Hajishengallis G, Metzger DJ, Michalek SM, Connell TD, Russell MW. Recombinant antigen-enterotoxin A2/B chimeric mucosal immunogens differentially enhance antibody responses and B7-dependent co-stimulation of CD4+ T cells. Infect. Immun. 69:252-261. (2001).
Huang Y, Hajishengallis G, Michalek SM. Construction and characterization of a Salmonella enterica serovar Typhimurium clone expressing a salivary adhesisn of Streptococcus mutans under control of the anaerobically inducible nirB promoter. Infect. Immun. 68:1549-1556. (2000).
Russell MW, Hajishengallis G, Childers NK, Michalek SM. Secretory immunity in defense against mutans streptococci. Caries Res. 33:4-15. (1999).
Hajishengallis G & Michalek SM. Current status of a mucosal vaccine against dental caries. Oral Microbiol. Immunol. 14:1-20. (1999).
Jespersgaard C, Hajishengallis G, Huang Y, Smith DJ, Russell MW, Michalek SM. Protective immunity against Streptococcus mutans infection in mice after intranasal immunization with the glucan-binding region of S. mutans glucosyltransferase. Infect. Immun. 67:6543-6549. (1999).
Russell MW, Wu H-Y, Hajishengallis G, Hollingshead SK, Michalek SM. Cholera toxin B subunit as an immunomodulator for mucosal vaccine delivery. Adv. Vet. Med. 41:105-114. (1999).
Jespersgaard C, Hajishengallis G, Greenway TE, Smith DJ, Russell MW, Michalek SM. Functional and immunologic characterization of two cloned regions of Streptococcus mutans glucosyltransferase-I. Infect. Immun. 67:810-816. (1999).
Harokopakis E, Hajishengallis G, Michalek SM. Effectiveness of liposomes possessing surface-linked B subunit of cholera toxin as an oral adjuvant system. Infect. Immun. 66:4299-4304. (1998).
Hajishengallis G, Russell MW, Michalek SM. Comparison of an adherence domain and a structural region of Streptococcus mutans antigen I/II in protective immunity against dental caries in rats after intranasal immunization. Infect. Immun. 66:1740-1743. (1998).
Harokopakis E, Hajishengallis G, Greenway T, M. W. Russell, Michalek MW. Mucosal immunogenicity of a recombinant Salmonella typhimurium-cloned heterologous antigen in the absence or presence of co-expressed cholera toxin A2/B subunits. Infect. Immun 65: 1445-1454. (1997).
Toida N, Hajishengallis G, Wu H-Y, Russell MW. Oral immunization with the saliva-binding region of Streptococcus mutans AgI/II genetically coupled to the cholera toxin B subunit elicits T helper cell responses in gut-associated lymphoid tissues. Infect. Immun 65: 909-915. (1997).
Hajishengallis G, Harokopakis E, Hollingshead SK, Russell MW, Michalek SM. Construction and oral immunogenicity of a Salmonella typhimurium strain expressing a streptococcal adhesin linked to the A2/B subunits of cholera toxin. Vaccine 14: 1545- 1548. (1996).
Russell MW, Wu H-Y, Hajishengallis G, Harokopakis E, Briles DE, Michalek SM, Mestecky J. IgA antibodies and mucosal immune protection. Period. Biol. 98: 413- 420. (1996).
Hajishengallis G, Michalek SM, Russell MW. Persistence of serum and salivary antibody responses after oral immunization with a bacterial protein antigen genetically linked to the A2/B subunits of cholera toxin. Infect. Immun. 64: 665-667. (1996).
Hajishengallis G, Hollingshead SK, Koga T, Russell MW. Mucosal immunization with a bacterial protein antigen genetically coupled to cholera toxin A2/B subunits. J. Immunol. 154: 4322-4332. (1995).
Hajishengallis G, Koga T, Russell MW. Affinity and specificity of the interactions between Streptococcus mutans antigen I/II and salivary components. J. Dent. Res. 73:1493-1502. (1994).
Hajishengallis G, Nikolova E, Russell MW. Inhibition of Streptococcus mutans adherence to saliva-coated hydroxyapatite by human secretory immunoglobulin A antibodies to the cell surface protein antigen I/II. Reversal by IgA1 protease cleavage. Infect. Immun. 60:5057-5064. (1992).
Hajishengallis G, Apostolopoulos AX & Koulourides T. An in vitro investigation of the effect of topical applications of strontium on the de- and remineralization of enamel. Odontostomatol. Progress 45:145-152. (1991).
Hajishengallis G & Apostolopoulos AX. Glucosyltransferase (GTF) and immunization against dental caries in humans. Odontostomatol. Progress 43:315-321. (1989).