“Researchers at the University of Pennsylvania have gained new insight into how different inflammatory conditions reinforce each other via trained innate immunity. Their work, which appeared in the April 27, 2022, advance online issue of Cell (https://doi.org/10.1016/j.cell.2022.03.043), “may pave the way to treat inflammatory comorbidities in a holistic manner,” senior author George Hajishengallis told BioWorld.

Hajishengallis is a professor of basic & translational science at the University of Pennsylvania’s School of Dental Medicine. The work began, he said with “a question we had about a paradox” in trained innate immunity. The idea that there is such a thing as trained innate immunity at all is relatively recent.”

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