Clinical research has long focused on ways to harness the actions of the immune system. From vaccines to immunotherapies, researchers have used their knowledge of the immune system to develop therapies to treat or prevent diseases from influenza to autoimmune disease and cancer.
Now, researchers from Penn’s School of Dental Medicine and international collaborators have investigated the effects of training the innate immune system in experimental models of two chronic inflammatory diseases: periodontitis and arthritis. They find that this “trained” immunity, or TRIM, leads to increased bone loss in these models. This study is published in Developmental Cell.
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