“Patients with one inflammatory disease are at greater risk of devel­oping another, often distinct, inflammatory comorbidity. Li et al. report in Cell that epigenetic rewiring of bone marrow (BM) progenitor cells as a result of one inflammatory disease can enhance susceptibility to a distinct disease.

Trained immunity describes how activation of the innate immune system by a particular stimulus can lead
to heightened innate responsiveness to subsequent exposures — it is consid­ered a form of innate immune memory. The process depends on epigenetic reprogramming of cells, and studies have indicated that systemic inflam­mation reprogram meshaematopoietic stem and progenitor cells (HSPCs) in the BM to show a long­term myeloid bias, referred to as ‘trained myelopoiesis’.”

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