“Patients with one inflammatory disease are at greater risk of developing another, often distinct, inflammatory comorbidity. Li et al. report in Cell that epigenetic rewiring of bone marrow (BM) progenitor cells as a result of one inflammatory disease can enhance susceptibility to a distinct disease.
Trained immunity describes how activation of the innate immune system by a particular stimulus can lead
to heightened innate responsiveness to subsequent exposures — it is considered a form of innate immune memory. The process depends on epigenetic reprogramming of cells, and studies have indicated that systemic inflammation reprogram meshaematopoietic stem and progenitor cells (HSPCs) in the BM to show a longterm myeloid bias, referred to as ‘trained myelopoiesis’.”
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