“Immune response is a balancing act: Too much can lead to inflammatory or autoimmune disease; too little could lead to a serious infection. Regulatory T cells, or Tregs, are important players in striking this balance, acting as “brakes” on the immune response so it doesn’t go overboard.
Consequently, controlling the numbers and activity of Tregs is crucial in maintaining health. New findings from a multi-institutional team, including the School of Dental Medicine’s George Hajishengallis, suggest that targeting the molecule DEL-1, which promotes the generation and immunosuppressive activity of Tregs, could be an effective way to treat conditions where taming an inflammatory or autoimmune response is desired.”
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