“Owing to a rare genetic mutation, individuals with leukocyte adhesion deficiency type 1 (LAD1) experience a suite of symptoms that trace back to an immune system dysfunction. Many have recurrent bacterial infections and gum disease so serious that they often lose their teeth at an early age.
In a new study in the Journal of Leukocyte Biology, School of Dental Medicine researchers and colleagues identified a novel strategy for addressing an underlying cause of LAD1 patients’ symptoms. In healthy people, the clearance of dying neutrophils, a “sweeping up” process known as efferocytosis, triggers resolution and regeneration in formerly inflamed tissues.”
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